Stop and disable the systemd-resolved service:
sudo systemctl stop systemd-resolved
sudo systemctl disable systemd-resolved

Remove the symbolic link for /etc/resolv.conf:
sudo rm /etc/resolv.conf

Create a new resolv.conf file with your desired DNS settings.
sudo bash -c 'echo -e "nameserver 192.158.42.53\nnameserver 192.168.42.54" > /etc/resolv.conf'

Optionally, make the resolv.conf file immutable to prevent it from being overwritten:
sudo chattr +i /etc/resolv.conf